Time-varying mobility and turnover of actomyosin ring components during cytokinesis in Schizosaccharomyces pombe
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چکیده
منابع مشابه
Actomyosin ring driven cytokinesis in budding yeast
Cytokinesis is the final process in the cell cycle that physically divides one cell into two. In budding yeast, cytokinesis is driven by a contractile actomyosin ring (AMR) and the simultaneous formation of a primary septum, which serves as template for cell wall deposition. AMR assembly, constriction, primary septum formation and cell wall deposition are successive processes and tightly couple...
متن کاملActin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.
Actin filaments and myosin II are evolutionarily conserved force-generating components of the contractile ring during cytokinesis. Here we show that in budding yeast, actin filament depolymerization plays a major role in actomyosin ring constriction. Cofilin mutation or chemically stabilizing actin filaments attenuate actomyosin ring constriction. Deletion of myosin II motor domain or the myosi...
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Eukaryotic cells ensure error-free progress through the cell cycle by monitoring (1) the completion of cell cycle events, (2) damage to critical cellular components, or (3) structural changes such as the attachment of kinetochores to the mitotic spindle. In the presence of damage, or in the face of a reduced capacity to complete essential events, cells are capable of delaying the cell cycle so ...
متن کاملType II Myosin Heavy Chain Encoded by the myo2 Gene Composes the Contractile Ring during Cytokinesis in Schizosaccharomyces pombe
We cloned the myo2 gene of Schizosaccharomyces pombe, which encodes a type II myosin heavy chain, by virtue of its ability to promote diploidization in fission yeast cells. The myo2 gene encodes 1,526 amino acids in a single open reading frame. Myo2p shows homology to the head domains and the coiledcoil tail of the conventional type II myosin heavy chain and carries putative binding sites for A...
متن کاملProper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1
Cytokinesis must be initiated only after chromosomes have been segregated in anaphase and must be terminated once cleavage is completed. We show that the fission yeast protein Etd1 plays a central role in both of these processes. Etd1 activates the guanosine triphosphatase (GTPase) Spg1 to trigger signaling through the septum initiation network (SIN) pathway and onset of cytokinesis. Spg1 is ac...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2021
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e20-09-0588